All Time Machine settings require a system restart to be applied.
Enable unsupported network volumes:
Enables Time Machine to connect to network volumes over more protocols.
Disable backup of system files:
Prevents Time Machine from backing up system files.
Disable Power Nap support:
Prevents Time Machine from backing up when the Power Nap compatible computer is asleep and Power Nap is enabled.
Do not ask to use newly connected disks:
Time Machine will not prompt when new disks are connected. To enable backup for a new device you will have to use Time Machines preferences.
Backup every X minute(s):
Time between Time Machine backups.
Thin or delete local snapshots:
If you are using Time Machine with an external disk, Time Machine will keep a copy of the latest backups on your internal drive. This is done to ensure that all changes to files and documents will be backed up even when you're not connected to your Time Machine disk, however it can take up significant amounts of disk space. Cocktail can thin (purge) or completely delete local backups (called snapshots) and free up the space used by Time Machine. Warning: By deleting the local Time Machine backups you reduce the effectiveness of your backups and you risk losing data.